We talked briefly about a something-a-mab drug at the meeting tonight and it sounded interesting. I found some Wikipedia links describing cytokines and IL-5 - amazing. They're worth a read...and then another...and another. There's also a link to a report discussing the use of a medication specifically to treat EE. At a conference last summer the anti-IL-5 medication was mentioned a couple of times but it was stressed that the process to make it to production, cleared by the FDA, and then matched to the right patients was a loooong process.
Katy - help?
The links:
Cytokine Interleukin Interleukin-5
Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis
Auteur(s) / Author(s)
STEIN Miguel L. (1) ; COLLINS Margaret H. (2) ; VILLANUEVA Joyce M. (3) ; KUSHNER Jonathan P. (4) ; PUTNAM Philip E. (5) ; BUCKMEIER Bridget K. (1) ; FILIPOVICH Alexandra H. (3) ; ASSA'AD Amal H. (1) ; ROTHENBERG Marc E. (1) ;Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, ETATS-UNIS(2) Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, ETATS-UNIS
(3) Division of Hematology /Oncology, Cincinnati Children's Hospital Medical Center, ETATS-UNIS
(4) Digestive Diseases, University of Cincinnati College of Medicine, ETATS-UNIS
(5) Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, ETATS-UNIS
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1 comment:
Wow - talk about your relaxing lunch-time read! If the language in the links reads like Greek to you, don't worry - you are not alone! All jokes aside, it can be difficult to sift through the science surrounding medications. The bottom line is that anti IL-5 medications (like mepolizumab) work more directly against the part of the immune systm that is suspected to be connected to the increased eosinophils in EoE. The long-term expectations for this drug (and others like it, such as reslizumab - another anti IL-5 med being studied) remain to be seen - how much of the drug is needed to decrease the eosinophils, whether the drugs will bring long-term improvement, side effects of the drug, etc are just SOME of the questions that still remain. As eg previously mentioned, it is a LOOONG process. Still, it is a hopeful possibility.
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